Phase II Study of Perifosine in Patients With Refractory and Relapsed Leukemia

Inclusion Criteria:

* Patients must have relapsed/refractory leukemias for which no standard therapies are anticipated to result in a durable remission. Patients with poor-risk myelodysplasia (MDS) \[i.e. refractory anemia with excess blasts (RAEB-1 or RAEB-2) by WHO classification\] and chronic myelomonocytic leukemia (CMML) are also candidates for this protocol. Relapsed/refractory leukemias include acute non-lymphocytic leukemia (AML) by WHO classification, acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), or chronic myelogenous leukemia (CML) in blast crisis. Patients with agnogenic myeloid metaplasia (AMM) are also eligible.
* ECOG performance status of 0-2
* Sexually active men and women who are not surgically sterile or post menopausal must use acceptable contraceptive methods (physician will discuss acceptable methods) during the time on study and for 4 weeks following the completion of treatment. Women of child-bearing potential (i.e., women who are pre-menopausal or not surgically sterile) must have a negative serum or urine pregnancy test within 2 weeks prior to beginning treatment on this trial.
* In the absence of rapidly progressing disease, the interval from prior treatment to time of study drug administration should be at least 2 weeks for cytotoxic agents, or at least five half-lives for noncytotoxic agents. Persistent chronic toxicities from prior chemotherapy must not be greater than grade 1.
* Patients must have the following clinical laboratory values:

  * Serum creatinine: \<= 2.0 mg/dl
  * Total bilirubin: \<=1.5x the upper limit of normal unless considered due to Gilbert's syndrome
  * Alanine aminotransferase (ALT), or aspartate aminotransferase (AST): \<= 3x the upper limit of normal unless considered due to organ leukemic involvement
* Must be able and willing to give written informed consent
* Age equal to or greater than 18 years

Exclusion Criteria:

* Uncontrolled intercurrent illness including, but not limited to uncontrolled infection, symptomatic congestive heart failure, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
* Active heart disease including myocardial infarction within previous 3 months, symptomatic coronary artery disease, arrhythmias not controlled by medication, or uncontrolled congestive heart failure
* Patients with a history of severe hyper-reactive airway system (e.g. active asthma, COPD)
* Patients receiving any other standard or investigational treatment for their hematologic malignancy
* Pregnant and nursing patients are excluded because the effects of perifosine on a fetus or nursing child are unknown.