Clinical trial · Observational
Comparison of I-124 PET/CT, F-18 FDG PET/CT & I-123 Whole Body Scintigraphy for Recurrent Thyroid CA
Comparison of I-124 PET/CT, F-18 FDG PET/CT and I-123 Whole Body Scintigraphy for Recurrent Thyroid Cancer Detection
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Abandoned
Summary
Brief summary (as posted)
The management of thyroid cancer patients with suspicion of recurrent disease based on rising/detectable levels of thyroglobulin (Tg) involves imaging with iodine-123 whole body scintigraphy (I-123 WBS) and F-18 FDG PET/CT. However, the disease is not always detected. The use of another iodine isotope (I-124) with positron emitting characteristics for PET/CT may allow better identification of recurrent disease, thus allowing for more patients to be treated with I-131 as a curative attempt.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| F-18 FDG | Drug | — | UNRESOLVED |
| Iodine-123 | Drug | — | UNRESOLVED |
| Iodine-124 | Drug | — | UNRESOLVED |
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria:- Patient at Nuclear Medicine clinic at Stanford University Medical Center * Treated thyroid cancer. * Detectable levels of Tg. * Referred for I-123 WBS and F-18 FDG PET/CT for detection of recurrent thyroid cancer. * Able to have a I-124 PET/CT the day after I-123 WBS and F-18 FDG PET/CT * Patients older than 18-year-old. * Patients with history of treated thyroid cancer and suspected recurrent thyroid cancer based on detectable levels of Tg. * Patients must have I-123 WBS and F-18 FDG PET/CT performed prior to the I-124 PET/CT. * Patients must understand and voluntarily sign an Informed Consent form after the contents have been fully explained to them. Exclusion Criteria:- Patients who are not eligible for I-123 WBS and F-18 FDG PET/CT. * Patients who cannot complete I-123 WBS and F-18 FDG PET/CT. * Pregnant women. * Healthy volunteers. * Patients participating in other research studies.
References
Publications (0)
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