Clinical trial · Interventional
A Dose-finding Study of MAL and HAL Photodynamic Therapy of Cervical Premalignant Lesions.
Methyl Aminolevulinate (MAL) and Hexaminolevulinate (HAL) Photodynamic Therapy (PDT)of Cervical Intraepithelial Lesions (SIL) - a Double-blind Dose-finding Study
NCT00369018CI-TRIAL-00004149completedPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study will determine the best drug (MAL or HAL) dosage for photodynamic therapy of cervical precancerous lesions (dysplasia) in women that are referred for conisation (surgery).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Dysplasia | Cervical Intraepithelial Neoplasia | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| methyl aminolevulinate (MAL) and hexaminolevulinate (HAL) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (6)
- type
- ACTIVE_COMPARATOR
- label
- MAL 3
- interventionNames
- Drug: methyl aminolevulinate (MAL) and hexaminolevulinate (HAL)
- type
- ACTIVE_COMPARATOR
- label
- MAL 12
- interventionNames
- Drug: methyl aminolevulinate (MAL) and hexaminolevulinate (HAL)
- type
- ACTIVE_COMPARATOR
- label
- HAL 10, 3
- interventionNames
- Drug: methyl aminolevulinate (MAL) and hexaminolevulinate (HAL)
- type
- ACTIVE_COMPARATOR
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Positive histology of CIN 1-3 Exclusion Criteria: * Patients with endocervical lesions * Patients with AGUS * Patients with invasive disease * Patients with porphyria * Patients sensitive to MAL and HAL
References
Publications (0)
Data not yet available
No reference posted for this study.