Clinical trial · Interventional
Study of Vinorelbine Liposomes Injection for Advanced Solid Tumors, Non-Hodgkin's Lymphoma or Hodgkin's Disease
A Phase 1 Study of Vinorelbine Liposomes Injection (VLI) for Treatment in Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma or Hodgkin's Disease
NCT00364676CI-TRIAL-00019172completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This Phase 1 study will determine the safety, tolerability, and pharmacokinetics of vinorelbine liposomes injection (VLI) in patients with advanced solid tumors, non-Hodgkin's lymphoma, or Hodgkin's disease.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hodgkins Disease | Hodgkin Lymphoma | ALIAS | 0.90 |
| Non-Hodgkins Lymphoma | Non-Hodgkin Lymphoma | ALIAS | 0.90 |
| Tumors | Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| VLI | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 1
- description
- Patients are dosed on Day 1 and Day 8 of a 21-day cycle.
- interventionNames
- Drug: VLI
- type
- EXPERIMENTAL
- label
- 2
- description
- Patients are dosed on Day 1 of a 21-day cycle.
- interventionNames
- Drug: VLI
Primary outcomes (1)
- measure
- Evaluate the safety and tolerability of VLI.
- timeFrame
- 21 Days
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Histologically confirmed solid tumor refractory to standard therapy or for which no standard therapy is known to exist, or relapsed and/or refractory non-Hodgkin's lymphoma or Hodgkin's disease 2. Adequate hematologic, hepatic and renal functions as defined by laboratory tests. 3. At least 18 years of age. 4. Have a life expectancy of at least 12 weeks. 5. Patients must give written informed consent. 6. ECOG or Zubrod performance status of 0, 1, or 2. Exclusion Criteria: 1. Primary tumors of central nervous system (CNS). Symptomatic brain metastases (unless patient is stable without requirement of steroids and/or antiseizure medications for at least 3 months) or leptomeningeal tumor involvement. 2. Prior chemotherapy or radiotherapy within 4 weeks prior to study entry (6 weeks for nitrosoureas and mitomycin C). 3. Planned concurrent systemic therapy and/or radiotherapy drug study treatment. 4. Use of investigational drugs, biologics or devices within 28 days prior to study treatment or planned use during the course of the study. 5. Active infection or any serious underlying medical condition, which would impair the ability of the patient to receive protocol treatment. 6. Prophylactic hematologic growth factors administered less than or equal to 2 weeks prior to start of therapy with VLI (excluding darbepoetin alfa, epoetin alfa). 7. Female patients who are pregnant or lactating. 8. Dementia or significantly altered mental status that would prohibit the understanding and giving of informed consent.
References
Publications (0)
Data not yet available
No reference posted for this study.