Clinical trial · Interventional
Chromoscopic Guided Endomicroscpy to Diagnose Colitis Associated Dysplasia
Diagnosis of Intraepithelial Neoplasia in Patients With Long Standing Ulcerative Colitis With Chromoscopic Guided Endomicroscopy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Timely diagnosis of intraepithelial neoplasias (premalignant condition)is of crucial importance for clinical management of ulcerative colitis. We assessed the value of combined chromoscopy and endomicroscopy for diagnosis of intraepithelial neoplasias in a randomised controlled trial. Endomicroscopy is a new device which enables microscopy of the mucosal layer during ongoing colonoscopy. Chromoscopy means topical staining of mucosal surface to unmask areas of interest, which are subsequently examined with the endomicroscopic system.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Intraepithelial Neoplasia | Intraepithelial Neoplasia | ONTOLOGY_EXACT | 0.98 |
| Ulcerative Colitis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endomicroscope | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Histological proof of neoplastic tissue (Intraepithelial neoplasia or cancer)
Secondary outcomes (1)
- measure
- Prediction of extent and severity of inflamed mucosa
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Clinically and histologically verified UC * Disease duration \>8 years * Colitis Activity Index ≤8 * Activity index of Truelove and Witts: mild Exclusion Criteria: * Known intraepithelial neoplasia or colorectal cancer * Coagulopathy (Prothrombin time \<50% of control, Partial thromboplastin time \>50 s) * Impaired renal function (Creatinine \>1.2 mg/dL) * Pregnancy or breast feeding * Inability to obtain informed consent * Known allergy to methylene blue or Fluorescein
References
Publications (0)
Data not yet available