Clinical trial · Interventional
"Red Morphine Drops" for Symptomatic Treatment of Dyspnoea in Lung Cancer
"Red Morphine Drops" for Symptomatic Treatment of Dyspnoea in Terminal Patients With Primary Lung Cancer or Lung metastases-a Pilot Study
NCT00338481CI-TRIAL-00005290completedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to test whether "red morphine drops" applied in the mouth are superior to an equivalent amount of morphine applied as subcutaneous injection for the relief of breathlessness in terminal patients suffering from primary lung cancer or lung metastases.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dyspnea | — | UNRESOLVED | — |
| Lung Neoplasms | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Morphine p.o. | Drug | — | UNRESOLVED |
| Morphine s.c. | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- 1
- interventionNames
- Drug: Morphine p.o.
- type
- ACTIVE_COMPARATOR
- label
- 2
- interventionNames
- Drug: Morphine s.c.
Primary outcomes (1)
- measure
- Dyspnea on a VAS scale
- timeFrame
- 1 hour
Secondary outcomes (1)
- measure
- Respiratory rate, pulse rate, oxygen saturation
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Primary lung cancer or lung metastases and * Moderate to severe dyspnea at rest (VAS equal to or more than 30) Exclusion Criteria: * Causal treatment of dyspnea possible and indicated * Not receiving opioids on a regular basis * Methadone treatment * Intolerance to morphine * Without understanding of patient information * Depressed consciousness * Oxygen treatment, if changed with-in 20 min before start * Short-acting opioids with-in 4 h before start * Inhalation therapy for bronchodilation with-in 20 min before start
References
Publications (0)
Data not yet available
No reference posted for this study.