Clinical trial · Interventional
Exercise in Improving Mobility and Reducing Fatigue and/or Weakness in Older Cancer Survivors
A RENEW Intervention for Elderly Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Exercise may help improve mobility and relieve fatigue and/or weakness in cancer survivors. It is not yet known whether exercise is more effective than standard therapy in improving mobility and reducing fatigue and/or weakness in older cancer survivors. PURPOSE: This randomized clinical trial is studying exercise to see how well it works compared to standard therapy in improving mobility and reducing fatigue and/or weakness in older cancer survivors.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Cancer | Malignant Bladder Neoplasm | CURATED_EXACT | 0.92 |
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
| Fatigue | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| complementary or alternative medicine procedure | Procedure | — | UNRESOLVED |
| exercise intervention | Behavioral | — | UNRESOLVED |
| fatigue assessment and management | Procedure | — | UNRESOLVED |
| physical therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Patient perception and pattern of change
- timeFrame
- 3 months of training followed by 6 and 12 months of no formal training
- description
- To explore the participant's perception and pattern of change in fatigue, weakness, physical activity level and functional status
Secondary outcomes (1)
- measure
- Structural and function changes
- timeFrame
- 3 months of training followed by 6 and 12 months of no formal training
- description
- To explore whether changes in muscle structure and function (strength and power production and metabolic function) and mobility occur following twelve weeks of training with RENEW
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Survivor of breast, prostate, colon, lung, lymphoma, ovarian, bladder, or esophageal cancer with no evidence of disease * At least moderate levels of fatigue and/or weakness * Impaired mobility but ambulatory and medically able to participate in an exercise regimen * No impaired knee flexion, defined as \< 90º PATIENT CHARACTERISTICS: * Folstein Mini-Mental Status Examination score ≥ 23 * No extreme claustrophobia * No diagnosed chronic fatigue syndrome/disorder * No neurological impairments, including the following: * Central nervous system disorder (e.g., multiple sclerosis or Parkinson's disease) * Neurological insult (cerebrovascular attack) that manifests in a mobility disorder * No myopathic disease (e.g., focal myopathy) that effects skeletal muscle structure/function * No rheumatological disease that has an effect on muscle and/or mobility (e.g., polymyalgia rheumatica) PRIOR CONCURRENT THERAPY: * More than 6 months since prior regular aerobic or resistance exercise * Regular exercise defined as 2-3 times per week * At least 6 months since prior cancer treatment (surgery, radiation, and/or chemotherapy ) * No concurrent cancer-related treatment other than hormonal therapy
References
Publications (1)
- DERIVEDLaStayo PC, Marcus RL, Dibble LE, Smith SB, Beck SL. Eccentric exercise versus usual-care with older cancer survivors: the impact on muscle and mobility--an exploratory pilot study. BMC Geriatr. 2011 Jan 27;11:5. doi: 10.1186/1471-2318-11-5. PMID 21272338