Clinical trial · Interventional
Endoscopic Surgery or Radiation Therapy in Treating Patients With Stage 0, Stage I, or Stage II Laryngeal Cancer of the Glottis
Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy [EaStER]
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Endoscopic surgery is a less invasive type of surgery for laryngeal cancer and may have fewer side effects and improve recovery. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether endoscopic surgery is more effective than radiation therapy in treating laryngeal cancer of the glottis. PURPOSE: This randomized phase II trial is studying endoscopic surgery to see how well it works compared with radiation therapy in treating patients with stage 0, stage I, or stage II laryngeal cancer of the glottis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| endoscopic surgery | Procedure | — | UNRESOLVED |
| laser surgery | Procedure | — | UNRESOLVED |
| radiation therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Feasibility
- measure
- Patient acceptability
Secondary outcomes (3)
- measure
- Voice analysis
- measure
- Quality of life
- measure
- Economic assessment
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Histologically confirmed squamous cell carcinoma of the glottic larynx, including tumors at the anterior commissure * Stage 0-II (Tis, T1, or T2a) * No clinical or radiological sign of nodal involvement * No evidence of distant metastases * Airway anatomy suitable for endoscopic excision PATIENT CHARACTERISTICS: * Fit to receive radical treatment as either radiotherapy or endoscopic excision * Life expectancy ≥ 2 years * No other cancer in the past 10 years except basal cell carcinoma of the skin or adequately treated carcinoma in situ of the uterine cervix * No vasculitic conditions adversely affecting radiotherapy * No other co-existing medical condition that would limit life expectancy * Not pregnant PRIOR CONCURRENT THERAPY: * No concurrent chemotherapy * No concurrent palliative treatment
References
Publications (0)
Data not yet available