Treatment of Acute Lymphoblastic Leukemia (ALL) in Younger Adults

This study is a multicenter trial of treatment for young ALL patients. All ALL patients will receive the same steroid pre-phase in order to evaluate sensitivity or resistance. Then, patients will be included into 3 specific trials according to biological features (immunophenotype, cytogenetics, and molecular biology). Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) 2005: * T ALL or B ALL non Ph (N=810 patients planned). * GRAALL 2005 R: B ALL non Ph CD20+ (N=220 patients planned). * GRAAPH 2005: ALL Ph+ (N=270 patients planned)

Sex

All

Minimum age

18 Years

Maximum age

59 Years

Inclusion Criteria:

* 18-59 years
* ALL newly diagnosed (blast \< 20%)
* Central Nervous System (CNS) positive or negative
* Signed written informed consent
* For GRAAPH trial only: t(9;22) or BCR- ABL positive

Exclusion Criteria:

* Lymphoblastic lymphoma
* ALL 3
* Chronic myeloid leukemia
* Severe organ condition

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