Clinical trial · Interventional
Intravenous (IV) Lidocaine for Opioid-refractory Pain
A Randomized, Placebo Controlled Phase II Study of Parenteral Lidocaine's Ability To Acutely Relieve Opioid Refractory Pain
NCT00321347CI-TRIAL-00007239withdrawnPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): No patients enrolled and clinician no longer at institution.
Summary
Brief summary (as posted)
Opioid medicines, like morphine, are the main treatment for severe cancer pain. Unfortunately, some patients suffer severe pain despite high doses of opioids. We hypothesize that intravenous lidocaine can quickly and effectively treat this kind of opioid-refractory pain.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neoplasms | Neoplasm | ONTOLOGY_EXACT | 0.90 |
| Pain | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lidocaine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Comparison of current pain scores before and after the 30 minute randomized intervention
Secondary outcomes (2)
- measure
- Preliminary assessment of the safety of intravenous lidocaine
- measure
- Identify parameters that positively or negatively predict response to lidocaine
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria * Advanced cancer patient (prognosis ≤6 mos) * Age ≥ 18 years old * Opioid-refractory pain * Steady state levels of adjunctive pain medications * Intravenous access * Has decision-making capacity * Hemodynamics: 85\<SBP\<210 mm Hg \& 55\<HR\<120 * EKG QTc ≤ 440 msec Exclusion Criteria * Methadone use * Myoclonus * Seizure disorder * History of ventricular arrhythmia * Allergy to amide local anesthetics * Evidence of cardiac ischemia by history or EKG * Currently receiving a parenteral local anesthetic * Pregnancy
References
Publications (0)
Data not yet available
No reference posted for this study.