Clinical trial · Observational
Multiple Biomarkers in Undiagnosed Pleural Effusion
Evaluation of Multiple Biomarkers in Serum and Pleural Fluid to Estimate the Probability of Cancer in Patients Presenting With an Undiagnosed Pleural Effusion
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): The study was terminated on completion of the Pilot Study phase.
Summary
Brief summary (as posted)
The purpose of this clinical trial is to evaluate the ability of various biomarkers measured in serum and/or pleural fluids to estimate the risk of finding cancer in patients with undiagnosed pleural effusions. An algorithm for prediction of the risk of finding cancer in the patient using an optimal combination of markers will be developed, and patients will be categorized as having a low, moderate, or high risk of finding cancer that might be used to more effectively triage patients.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pleural Effusion | — | UNRESOLVED | — |
| Pleural Effusion, Malignant | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Procedure/Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Pts scheduled to remove pleural fluid
- interventionNames
- Procedure: Procedure/Surgery
Primary outcomes (0)
[]Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: TRAINING SET INCLUSION CRITERIA * Subjects able to understand and sign Informed Consent; * Males or females \>18 years of age; * Have a pleural effusion of known or unknown origin; * Scheduled for a diagnostic and/or therapeutic procedure to remove pleural fluid. VALIDATION SET INCLUSION CRITERIA * Subjects able to understand and sign Informed Consent; * Males or females \>18 years of age; * Have a pleural effusion of unknown origin; * Scheduled for a diagnostic procedure to remove pleural fluid. Exclusion Criteria: TRAINING SET EXCLUSION CRITERIA * For Subjects currently receiving chemotherapy and/or radiation therapy- Subjects who have received chemotherapy and/or radiation therapy must have completed these modalities one month before entering the study. * Females known to be pregnant; * Already entered into the study; * Unable or unwilling to provide informed consent or is there a high risk that the subject may not comply with the protocol requirements VALIDATION SET EXCLUSION CRITERIA * For Subjects currently receiving chemotherapy and/or radiation therapy- Subjects who have received chemotherapy and/or radiation therapy must have completed these modalities one month before entering the study. * Females known to be pregnant; * Already entered into the study; * Unable or unwilling to provide informed consent or is there a high risk that the subject may not comply with the protocol requirements
References
Publications (0)
Data not yet available