Effect of Diazoxide on the Obesity Secondary to Hypothalamic-pituitary Lesions

Inclusion Criteria:

* Age 6 to 18 years
* Obesity with body mass index \> 97 percentile or \> 2 SD
* Hypothalamic-pituitary lesions not evolutive
* Hyperinsulinemia defined by insulin peak after oral glucose tolerance test\>100 UI/L
* Absence of diabetes mellitus defined by basal plasma glucose \< 1.2 g/L and glucose peak after oral glucose tolerance test \< 2 g/L and HbA1c \< 7 %
* Hormonal replacement therapy stable from at least three months excluding the treatment of diabetes insipidus which can be adjusted
* Normal plasma thyroxine
* Written informed consent of the children and the parents

Exclusion Criteria:

* evolutive lesion
* recent surgery or radiotherapy (\< 6 months)
* modification of hormonal replacement therapy during the three previous months
* diabetes mellitus defined by basal plasma glucose \> 1.2 g/L and glucose peak after oral glucose tolerance test \> 2 g/L and HbA1c \> 7 %
* renal or hepatic failure
* uncontrolled hypertension
* hypersensitivity to benzothiazine drugs
* pregnancy
* difficulties to understand the protocol