Vatalanib and Everolimus in Treating Patients With Advanced Solid Tumors

DISEASE CHARACTERISTICS:

* Histologically confirmed solid tumor with radiographic evidence of metastatic disease

  * No standard therapy exists (phase I)
  * Unresectable or metastatic renal cell carcinoma (phase Ib)

PATIENT CHARACTERISTICS:

* Karnofsky performance status 70-100%
* Absolute neutrophil count ≥ 1,500/mm³
* Platelet count ≥ 100,000/mm³
* Hemoglobin ≥ 9 g/dL
* AST or ALT ≤ 2.5 times upper limit of normal (ULN)
* Total cholesterol \< 300 mg/dL
* Triglycerides \< 350 mg/dL
* Bilirubin ≤ 1.5 times ULN
* Creatinine ≤ 1.5 times ULN OR creatinine clearance \> 40 mL/min
* Negative proteinuria by dip stick OR total urinary protein ≤ 500 mg
* No uncontrolled high blood pressure, history of labile hypertension, or history of poor compliance with antihypertensive regimen
* No unstable angina pectoris
* No symptomatic congestive heart failure (New York Heart Association class III or IV heart disease)
* No uncontrolled serious cardiac arrhythmia (symptomatic supraventricular tachycardia or any ventricular tachycardia/fibrillation)
* No myocardial infarction in the past 6 months
* No uncontrolled diabetes
* No interstitial pneumonia or extensive and symptomatic interstitial fibrosis of the lung
* No active or uncontrolled infection
* No uncontrolled hyperlipidemia
* No chronic renal disease
* No acute or chronic liver disease (e.g., hepatitis or cirrhosis)
* No impaired gastrointestinal (GI) function OR GI disease that may significantly alter the absorption of vatalanib or everolimus, including any of the following:

  * Ulcerative disease
  * Uncontrolled nausea and vomiting with solid food
  * Watery diarrhea \> 5 times daily
  * Malabsorption syndrome
  * Bowel obstruction
  * Inability to swallow the tablets
* No confirmed HIV infection
* Not pregnant
* Negative pregnancy test
* Fertile patients must use effective contraception
* No other concurrent severe and/or uncontrolled medical condition that would preclude study participation

PRIOR CONCURRENT THERAPY:

* Recovered from prior therapy
* No prior antivascular endothelial growth factor therapy
* More than 4 weeks since prior major surgery\* (laparotomy)
* More than 2 weeks since prior minor surgery\*
* More than 4 weeks since prior chemotherapy (6 weeks for mitomycin C or nitrosoureas)
* More than 6 weeks since prior antibody therapy
* More than 2 weeks since prior biologic/immunotherapy
* More than 2 weeks since prior limited-field radiotherapy
* More than 4 weeks since prior full-field radiotherapy
* More than 4 weeks since prior investigational agents
* Prior transfusions allowed provided blood counts are stable for \> 2 weeks
* Concurrent epoetin alfa allowed
* No concurrent warfarin or similar oral anticoagulants that are metabolized by the cytochrome P450 system

  * Heparin and low molecular weight heparin allowed NOTE: \*Insertion of a vascular access device is not considered major or minor surgery