Clinical trial · Observational
Lung Cancer Biomarkers and Screening
NYU Lung Cancer Biomarker Center
NCT00301119CI-TRIAL-00110827NYULCBCrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Screening tests that use biomarkers may help doctors find tumor cells early and plan effective treatment for lung cancer. PURPOSE: This clinical trial is studying biomarkers in screening participants for lung cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- lung cancer screening cohort
- description
- observational only. no intervention. current, former and never smokers over age 50 without history of cancer, except for non melanoma skin cancer, no previous treatment with chemotherapy.
- label
- r/o lung cancer
- description
- observational only. no intervention. patients with CT findings suspicious for lung cancer who are undergoing bronchoscopy and/or surgery.
Primary outcomes (1)
- measure
- Lung cancer diagnosis as measured by CT scan findings and pathology findings annually
- timeFrame
- 07/01/2015
Secondary outcomes (1)
- measure
- Precancerous lung nodules as measured by CT scan findings and pathology findings annually
- timeFrame
- 07/01/2015
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS:
* Screening Cohort
* At high- or low-risk for lung cancer
* Smoking history ≥ 20 pack years\*
* With or without workplace exposure to asbestos
* NOTE: \* Participants with \< 20 pack years of smoking are eligible if 50 years of age or older
* Rule-Out Lung cancer group
* Referred for evaluation of suspicious nodules with 1 of the following diagnoses:
* Lung cancer
* Nonmalignant nodules (control group)
PATIENT CHARACTERISTICS:
* Not pregnant
* No prior malignancy except nonmelanoma skin cancer
PRIOR CONCURRENT THERAPY:
* Not specifiedReferences
Publications (3)
- RESULTGreenberg AK, Rimal B, Felner K, Zafar S, Hung J, Eylers E, Phalan B, Zhang M, Goldberg JD, Crawford B, Rom WN, Naidich D, Merali S. S-adenosylmethionine as a biomarker for the early detection of lung cancer. Chest. 2007 Oct;132(4):1247-52. doi: 10.1378/chest.07-0622. PMID 17934114
- RESULTGreenberg AK, Lu F, Goldberg JD, Eylers E, Tsay JC, Yie TA, Naidich D, McGuinness G, Pass H, Tchou-Wong KM, Addrizzo-Harris D, Chachoua A, Crawford B, Rom WN. CT scan screening for lung cancer: risk factors for nodules and malignancy in a high-risk urban cohort. PLoS One. 2012;7(7):e39403. doi: 10.1371/journal.pone.0039403. Epub 2012 Jul 2. PMID 22768300
- RESULTRom WN, Goldberg JD, Addrizzo-Harris D, Watson HN, Khilkin M, Greenberg AK, Naidich DP, Crawford B, Eylers E, Liu D, Tan EM. Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers. BMC Cancer. 2010 May 26;10:234. doi: 10.1186/1471-2407-10-234. PMID 20504322