Clinical trial · Interventional
Liver Transplantation With ADV-TK Gene Therapy Improves Survival in Patients With Advanced Hepatocellular Carcinoma
NCT00300521CI-TRIAL-00000295completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Previous rather poor results in liver transplantation (LT) of patients with advanced hepatocellular carcinoma (HCC) have made the application of LT very limited in treatment of HCC. The advantages of ADV-TK gene therapy highlight its potentiality as adjuvant treatment for HCC patients after LT. We reported here the improved outcome of LT with combined treatment of ADV-TK gene therapy in patients with intermediate or advanced HCC.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Liver Transplantation | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ADV-TK (adenovirus-thymidine kinase enzyme) gene therapy | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (6)
- measure
- overall survival rate at one year
- measure
- overall survival rate at two year
- measure
- overall survival rate at three year
- measure
- overall recurrence-free survival rate at one year
- measure
- overall recurrence-free survival rate at two year
- measure
- overall recurrence-free survival rate at three year
Secondary outcomes (5)
- measure
- AFP level before and after liver transplantation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 0 Years
Show eligibility criteria text
Inclusion Criteria: * Clinical diagnosis of advanced hepatocellular carcinoma with no metastasis in lungs and bones * Accept Liver Transplantation Exclusion Criteria: * Small hepatocellular carcinoma * Advanced hepatocellular with metastasis in lungs and bones
References
Publications (0)
Data not yet available
No reference posted for this study.