Clinical trial · Interventional
Study of Amiodarone Given Before Lung Surgery to Prevent Atrial Fibrillation After Lung Resection
Phase III Study of Preoperative Amiodarone for Prevention of Atrial Fibrillation After Lung Resection
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Unable to accrual total number of participants during study period.
Summary
Brief summary (as posted)
Atrial fibrillation is a very common complication of pulmonary resection. Patients who develop atrial fibrillation require additional treatment and are more likely to stay in the hospital for longer period of time increasing the costs associated with the operation. We propose a randomized controlled trial to see if oral amiodarone given for one week before surgery can prevent atrial fibrillation after pulmonary resection. We plan to evaluate the incidence of atrial fibrillation in patients who received preoperative amiodarone and compare them to the incidence of atrial fibrillation in patients who did not received preoperative amiodarone.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Atrial Fibrillation | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Amiodarone | Drug | — | UNRESOLVED |
| Control arm, standard care | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 1 - Amiodarone
- description
- Perioperative amiodarone
- interventionNames
- Drug: Amiodarone
- type
- ACTIVE_COMPARATOR
- label
- 2 - Control
- description
- Control arm, standard care with no perioperative amiodarone
- interventionNames
- Other: Control arm, standard care
Primary outcomes (1)
- measure
- Incidence of Post-operative Atrial Fibrillation
- timeFrame
- 30 days
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Resectable lung nodule or mass Exclusion Criteria: * Allergy to amiodarone * Currently taking amiodarone * Documented atrial fibrillation within past 12 months * Known pulmonary fibrosis * Known hepatic dysfunction * Thyroid disease * 2nd or 3rd degree heart block * Severe SA node disease * Bradycardia-induced syncope * Pregnancy
References
Publications (0)
Data not yet available