Clinical trial · Observational
Determination of Amifostine Levels During Radiation Therapy
Serial Blood and Salivary Sampling for Validation of Quantitative Amifostine Assays
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Currently, there are no published methods for easily determining the level of amifostine in the blood or saliva. A method has been developed within the Department of Radiation Oncology by Drs. Douglas Spitz and Gurminder Sidhu, within the Spitz Lab. This method has been tested using both animal sampling and expired blood (obtained from DeGowin blood center) mixed with amifostine. If the method proves successful, it could then be used as a tool to quantify blood and salivary amifostine levels and possibly correlate them to treatment efficacy or limiting adverse events using amifostine. A better method of treatment, either increasing the efficacy of amifostine or reducing its unwanted side effects, could then be developed.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood and salivary sampling of amifostine | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Amifostine
- description
- Those individuals enrolled who have received amifostine as part of standard care.
- interventionNames
- Procedure: Blood and salivary sampling of amifostine
Primary outcomes (0)
[]Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Ability to understand and willingness to sign a written informed consent document. * Receiving radiation treatment at University of Iowa Hospitals and Clinics. * Voluntarily elected to receive amifostine during treatment Exclusion Criteria: * none
References
Publications (0)
Data not yet available