Clinical trial · Interventional
Radiation Therapy in Treating Patients With Cervical Cancer
A Pilot Study of MR-Guided High Dose Rate Brachytherapy With MR Image Acquisition for Patients With Cervical Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. Giving radiation therapy in different ways may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving external-beam radiation together with internal radiation works in treating patients with cervical cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| brachytherapy | Radiation | — | UNRESOLVED |
| radiation therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Feasibility
- measure
- Comparison of dose-volume estimations based on 3D imaging-based treatment planning, with the traditional point dose method based on orthogonal radiographs
Secondary outcomes (6)
- measure
- Tolerance
- measure
- Toxicity
- measure
- Correlate three-dimensional dose-volume histograms of organs at risk with treatment toxicity
- measure
- Disease status
- measure
- Time and patterns of relapse
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Histologically confirmed carcinoma of the cervix of 1 of the following cellular subtypes: * Squamous cell * Adenocarcinoma * Adenosquamous cell * Stages IB-IVA disease * Stage IVB disease allowed provided the impact on the quality of life is tremendous (e.g., "frozen pelvis" or massive pelvic disease and fistula formation, severe pain, or bleeding) * Measurable and/or evaluable disease on MRI PATIENT CHARACTERISTICS: * ECOG performance status 0-2 * No physical or physiological capacity that would preclude study treatment * No cognitively impaired patients who cannot provide informed consent * Not pregnant or nursing * Negative pregnancy test * No contraindication to MRI, including any of the following: * Weight \> 136 kg * Allergy to MR contrast agent * Pacemakers, cerebral aneurysm clips, shrapnel injury, or implantable electronic devices * No significant unrelated systemic illness * No serious infections * No significant cardiac, pulmonary, hepatic, or other organ dysfunction that would preclude study treatment * Must be medically fit to receive anesthesia PRIOR CONCURRENT THERAPY: * No prior definitive brachytherapy procedures * Ring implants or intravaginal cones for the relief of excessive bleeding allowed * No prior definitive surgical oncologic procedures (e.g., radical hysterectomy) * Concurrent chemotherapy, immunotherapy, or hormonal therapy allowed
References
Publications (0)
Data not yet available