Capecitabine Associated With Weekly Paclitaxel in Metastatic Breast Cancer.

Inclusion Criteria:

* Femal patient aged \> 18 years
* Histologically proven breast adenocarcinoma
* HER2 negative receptors
* previously received first or second line chemotherapy for metastatic disease
* previously treated with anthracycline and/or docetaxel in adjuvant and/or as first or second line therapy
* presence of one or several evaluable metastatic lesion(s)
* presence of at least one target lesion not previously irradiated
* previously treated with hormonotherapy in adjuvant or in metastatic line (treatment will be ceased upon patient registration in the study)
* ECOG Performance status \< 2
* adequate biological values
* patient who has clearly given her consent by signing on informed consent form prior to participation

Exclusion Criteria:

* patient previously treated with paclitaxel or capecitabine for metastatic breast cancer
* patient with only local metastatic disease (with the exception of axillary lymph nodes)
* active symptomatic brain metastasis
* patient with an history of significant cardiovascular impairment (congestive heart failure\> NYHA grade II, unstable angina or myocardial infraction within the past six months or serious cardiac arrhythmia)
* peripheric neuropathy grade ≥ 2
* history of another malignancy within past 5 years that could confound diagnosis or staging of breast cancer (with the exception of in situ cacinoma of the cervix or adequately treated basel cell carcinoma of the skin)
* patient with any medical or psychiatric condition that, in the opinion of the Principal Investigator, would preclude her from participating in this study
* patient with a known allergy to one or several of the study compounds
* patients who may not be regularly available due to geographical, social or family reasons
* history of renal, hepatic or metabolic pathology that could preclude with metabolism or elimination of the study product
* deficiencies of the upper intestinal tract, malabsorption syndrome
* patient who is pregnant, breast-feeding or using inadequate contraception