Clinical trial · Observational
Study of the Effects of Chemotherapy on Memory and Other Mental Functions in Women With Breast Cancer
A Prospective, Longitudinal Investigation of the Neuropsychological and Psychosocial Effects of Cancer Therapy
NCT00260975CI-TRIAL-00029649completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Many breast cancer patients treated with chemotherapy complain of problems with concentration and memory. This has been referred to as chemo fog. The current study is investigating this phenomenon by measuring mental function of breast cancer patients prior to and after exposure to chemotherapy, and by comparing mental function in those patients who receive chemotherapy and those who do not.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Chemotherapy patients
- description
- Breast cancer patients treated with adjuvant chemotherapy of various types.
- label
- Hormonal patients
- description
- Breast cancer patients treated with adjuvant hormonal therapy but not chemotherapy.
Primary outcomes (0)
[]Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 50 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * stage I or II breast cancer; woman; 50-65 years old; post-menopausal Exclusion Criteria: * history of previous cancer or chemotherapy; significant neurological or psychiatric history
References
Publications (3)
- RESULTStewart A, Collins B, Mackenzie J, Tomiak E, Verma S, Bielajew C. The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study. Psychooncology. 2008 Feb;17(2):122-30. doi: 10.1002/pon.1210. PMID 17518411
- RESULTCollins B, Mackenzie J, Stewart A, Bielajew C, Verma S. Cognitive effects of chemotherapy in post-menopausal breast cancer patients 1 year after treatment. Psychooncology. 2009 Feb;18(2):134-43. doi: 10.1002/pon.1379. PMID 18551510
- RESULTCollins B, Mackenzie J, Stewart A, Bielajew C, Verma S. Cognitive effects of hormonal therapy in early stage breast cancer patients: a prospective study. Psychooncology. 2009 Aug;18(8):811-21. doi: 10.1002/pon.1453. PMID 19085975