Clinical trial · Interventional
High-dose Periop Statins for Prevention of DVT
High-dose Statin Therapy in the Perioperative Period and DVT Prevention.
NCT00259662CI-TRIAL-00024972completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is designed to determine if the use of atorvastatin (Lipitor), a member of the HMG coA reductase inhibitor class of drugs referred to as statins, will reduce inflammatory responses and deep vein thrombosis formation when given in high doses in the perioperative period.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gynecologic Oncological Pelvic/Abdominal Surgery | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| atorvastatin | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Decrease in incidence of deep vein thrombosis
Secondary outcomes (1)
- measure
- Decrease in inflammatory mediator release.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * gynecologic tumor scheduled for resection Exclusion Criteria: * prior reaction to statins * renal insufficiency * liver disease * h/o alcoholism * prior h/o DVT or hypercoagulability * concurrent medications that significantly affect cytochrome P450 3A4 * breast feeding or pregnancy
References
Publications (1)
- DERIVEDLippi G, Favaloro EJ, Sanchis-Gomar F. Venous thrombosis associated with HMG-CoA reductase inhibitors. Semin Thromb Hemost. 2013 Jul;39(5):515-32. doi: 10.1055/s-0033-1343892. Epub 2013 Apr 29. PMID 23629822