Clinical trial · Interventional
Melphalan With BBBD in Treating Patients With Brain Malignancies
Intra-Arterial Melphalan (L-Phenylalanine Mustard) Administered in Conjunction With Osmotic Blood-Brain Barrier Disruption in Patients With Brain Malignancies: A Phase I Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Other competing clinical trials affecting enrollment
Summary
Brief summary (as posted)
RATIONALE: Drugs used in chemotherapy, such as melphalan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving drugs directly into the arteries around the tumor may kill more tumor cells. Mannitol may open the blood vessels around the brain \[Blood-Brain Barrier Disruption (BBBD)\]and allow melphalan to be carried directly to the brain tumor. Giving melphalan together with BBBD may be an effective treatment for central nervous system cancer. PURPOSE: This phase I trial is studying side effects and best dose of melphalan when given together with mannitol in treating patients with central nervous system cancer.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain and Central Nervous System Tumors | — | UNRESOLVED | — |
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Metastatic Cancer | Malignant Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Melphalan | Drug | Melphalan | ALIAS |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- All subjects
- interventionNames
- Drug: Melphalan
Primary outcomes (1)
- measure
- Maximum tolerated dose (MTD)of Melphalan as measured by NCI common toxicity criteria (CTC) v2 toxicities
- timeFrame
- 5 years
- description
- MTD = dose of Melphalan that produces grade 3 neurotoxicity in 33% of subjects
Secondary outcomes (1)
- measure
- Efficacy of chemotherapy regimen as measured by clinical and radiographic response from first day of treatment
- timeFrame
- 5 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 120 Years
Show eligibility criteria text
INCLUSION CRITERIA: * Signed written informed consent form in accordance with institutional guidelines * Histologically confirmed primary or metastatic CNS malignancy (Patients with metastatic disease must have histological confirmation of the primary cancer AND confirmation by surgical specimen, cerebrospinal fluid cytology, elevated tumor markers, or clinical evidence of CNS involvement) * Single or multiple cerebellar or cerebral cortex lesions allowed * Life expectancy at least 60 days * Radiographically evaluable disease by MRI or CT scan * Age 18 years or older * At least 28 days since prior radiotherapy (systemic, cranial, and/or spinal) * At least 28 days since prior chemotherapy (42 days for nitrosoureas) * Adequate cardiac and pulmonary function to tolerate general anesthesia * Performance status of Eastern Cooperative Oncology Group (ECOG) 0-2 * Other tumor masses in the spinal cord allowed provided there is no radiographic or clinical evidence of spinal cord block * Available for follow-up for at least one year following completion of treatment * Fertile patients must use effective contraception for 2 months prior to, during, and for 3 months after study participation * Pre-treatment lab tests within 14 days prior to initiation of treatment: * White blood cell count (WBC) \> 2,500/mm\^3 * Absolute granulocyte count \> 1,200/mm\^3 * Platelet count \> 100,000/mm\^3 * Hematocrit \> 30% (transfusion allowed) * Bilirubin ≤ 2 times upper limit of normal (ULN) * Serum glutamic oxaloacetic transaminase (SGOT) ≤ 3 times ULN * Creatinine ≤ 2 times ULN * Subjects with history of smoking or emphysema require diffusing capacity of lung for carbon monoxide (DLCO) ≥ 80% of predicted value for age * Histological sections submitted for pathology review EXCLUSION CRITERIA: * Radiographic evidence of excessive intra-cranial mass effect and/or spinal block * Known hypersensitivity or intolerance to melphalan * NCI CTC Grade 3 or greater baseline neurologic symptoms * Immunologically compromised (Concurrent corticosteroids for tumor edema allowed) * Unable to tolerate general anesthesia * Pregnant, positive human chorionic gonadotropin (HCG) test, or lactating * HIV positive * Receiving concurrent radiotherapy or immunotherapy * Serious illness that would preclude study participation
References
Publications (0)
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