Effects of Carboplatin and Gemcitabine on Stage IIIB Pleural Effusion and Stage IV Lung Cancer

Inclusion Criteria:

* Untreated, stage IIIB with pleural effusion
* Untreated, Stage IV, non-small cell lung cancer
* Recurrent after surgery if no previous radiation therapy or chemotherapy were administered as part of their primary treatment, except for palliative radiotherapy
* 18 years of age or older
* ECOG PS 0, 1 or 2
* At Least one target lesion according to the RECIST Criteria
* Adequate organ and marrow function

Exclusion Criteria:

* Previous cancer history unless they have had curative treatment completed at least 5 years prior to entry.
* No previous radiotherapy, chemotherapy or immunotherapy for NSCLC, except for radiation therapy to the brain to control metastasis, bone to control pain, or lung to relieve bronchial obstruction.
* No radiation therapy for any previous cancer to more than 25% of bone marrow.
* Uncontrolled, intercurrent illness
* Non-study corticosteroids
* Pregnant women
* Peripheral neuropathy greater than grade 1
* Uncontrolled seizures, central nervous system disorders
* Major surgery within 4 weeks of the start of study treatment
* Lack of complete recovery from major surgery.
* Glaucoma
* Lack of physical integrity of upper gastrointestinal tract, inability to swallow tablets
* Severe acquired or hereditary immunodeficiency
* Patients with brain metastases must receive definitive treatment (radiation, surgery or both) and be clinically and radiologically stable for 4 weeks \& off corticosteroids for at least 2 weeks prior to randomization.