T-cell Depleted Donor Lymphocyte Infusion (DLI)for Acute Myeloid Leukemia (AML) or High Risk Myelodysplastic Syndrome (MDS)

Inclusion Criteria:

1. Confirmed diagnosis of AML or high risk MDS in the following disease stages: Induction failure, first or subsequent remission, or untreated first relapse.
2. Patient must have an HLA-compatible donor willing and capable of donating peripheral blood stem cells preferably or bone marrow progenitor cells using conventional techniques, and lymphocytes if indicated (HLA-compatible defined as 5/6 or 6/6 matched related or 6/6 molecular matched unrelated donor)
3. Both patient and donor must sign written informed consent forms.
4. Patients must have:

   * ECOG PS \</= 2;
   * Ejective fraction \> 40%;
   * DLCO \> 40% of predicted;
   * Serum bilirubin \</= 1.5x institutional upper limit of normal;
   * SGPT (ALT) and SGOT (AST) \</= 2.5x institutional upper limit of normal;
   * Serum creatinine \</= 2x upper limit of normal;
   * Creatinine clearance \>/= 60mL/min. However, renal dysfunction is not an absolute contraindication for NMT as dialysis can be performed during NMT.

Exclusion Criteria:

1. Not fulfilling any of the inclusion criteria
2. Active life-threatening infection
3. Overt untreated infection
4. HIV positivity, hepatitis B or C antigen positivity with active hepatitis
5. Pregnant or lactating women
6. Donor contraindication (HIV seropositive confirmed by Western blot; hepatitis B antigenemia)
7. Unable to donate bone marrow or peripheral blood due to concurrent medical condition