Clinical trial · Interventional
Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB
Evaluation of Lidocaine Continuous Intravenous Administration for Postoperative Recovery After Colorectal Surgery
NCT00236249CI-TRIAL-00004434completedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to check if lidocaine intravenous administration during surgery and 24 hours after surgery, associated with standardised management of the patient, helps to accelerate recovery and to improve the quality of recovery, after surgery for colic or rectal neoplasms.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lidocaine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Readiness for discharge, checked twice a day
Secondary outcomes (10)
- measure
- Pain every 4 hours the first day after surgery, then twice a day
- measure
- Morphine consumption: dose of titration, then twice a day
- measure
- Time of transit recovery
- measure
- Physical rehabilitation score daily
- measure
- Psychomotor test daily until reaching of preoperative values
- measure
- Quality of recovery score at 1st, 3rd, and 6th day
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Colorectal neoplasm * Radical surgery * Median incision Exclusion Criteria: * American Society of Anesthesiologists (ASA) score equal to or up to 3 * Unwilling or unable to use patient-controlled analgesia (PCA) * Chronic consumption of opioids * Chronic drug or alcohol abuse * Chronic pain * Unable to read or write text * Inflammatory disease of intestinal tract * Allergy to morphine * Allergy to lidocaine * Severe atrioventricular conduction dysfunction without stimulator * Porphyry * Uncontrolled epilepsy * History of malign hyperthermia * Severe cardiac failure * Hepatic failure * Myasthenia * Treatment with beta blockers, antiarrhythmic calcium blockers, sultopride, nonselective monoamine oxidase inhibitor (MAOI) * Locoregional anaesthesia planned * Associated surgery concerning liver, pancreas, or gall bladder * Laparoscopic surgery * Severe psychiatric pathology * Refusal of the patient
References
Publications (0)
Data not yet available
No reference posted for this study.