Standard Palliative Care Versus Standard Palliative Care Plus Polychemotherapy in Metastasized Malignant Melanoma

The purpose of this multicenter study is to examine whether the proposed randomized treatment regime results in a significantly longer survival time and higher quality of life than any additionally applied multiple chemotherapy according to the CVD- scheme. So far neither established treatment regimes nor reliable data exist for the second-line chemotherapy of metastatic malignant melanoma. Patients are therefore mostly treated with single or multiple chemotherapeutics or/and immunomodulatory therapeutics. These regimes however imply often not only a higher toxicity but show rarely a response rate higher than 10%.

Sex

All

Minimum age

18 Years

Maximum age

75 Years

Inclusion Criteria:

* histological diagnosis of metastatic melanoma (stage IV)
* progressive disease after first-line chemotherapy or immuno-chemotherapy
* Karnofsky-index \> 60%
* informed consent

Exclusion Criteria:

* Uvea melanoma
* another primary malignancy except basal cell carcinoma or cervical carcinoma in situ
* severe and/or uncontrolled medical disease (diabetes mellitus, cardiac insufficiency)

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