Clinical trial · Interventional
Trial Comparing Radioactive Seed Localization to Standard Procedure for Non-palpable Breast Cancers
A Prospective, Randomized, Controlled Trial of Radioguided Seed Localization Versus Standard Needle Localization of Nonpalpable Breast Cancers
NCT00225927CI-TRIAL-00004492completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether a new surgical technique (radioguided seed localization) for localizing nonpalpable breast tumours is better than the standard technique (needle localization).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer Invasive Nos | Breast Carcinoma In Situ | PROBABILISTIC | 0.70 |
| Stage 0 Breast Carcinoma | Breast Carcinoma | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| radioguided seed localization for nonpalpable breast cancers | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Compare the number of positive margins following excision of the nonpalpable breast tumours for the two different surgical techniques
- timeFrame
- immediate post-operative pathology results
Secondary outcomes (1)
- measure
- Compare procedure times, complications and volume of tissue excised for both techniques
- timeFrame
- intra-operative
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed invasive or in situ breast carcinoma * Nonpalpable breast tumour * Candidate for breast conserving surgery (BCS) based on clinical and radiologic evaluation Exclusion Criteria: * Histological confirmation more than 3 months from enrollment * Pregnancy or lactation * Contraindication to BCS or patient requests mastectomy * Age less than 18 years * Male patient
References
Publications (2)
- DERIVEDReedijk M, Hodgson N, Gohla G, Boylan C, Goldsmith CH, Foster G, Cornacchi SD, McCready D, Lovrics PJ. A prospective study of tumor and technical factors associated with positive margins in breast-conservation therapy for nonpalpable malignancy. Am J Surg. 2012 Sep;204(3):263-8. doi: 10.1016/j.amjsurg.2012.03.007. Epub 2012 Jul 12. PMID 22794705
- DERIVEDLovrics PJ, Goldsmith CH, Hodgson N, McCready D, Gohla G, Boylan C, Cornacchi S, Reedijk M. A multicentered, randomized, controlled trial comparing radioguided seed localization to standard wire localization for nonpalpable, invasive and in situ breast carcinomas. Ann Surg Oncol. 2011 Nov;18(12):3407-14. doi: 10.1245/s10434-011-1699-y. Epub 2011 Apr 30. PMID 21533657