Clinical trial · Interventional
Comparison Between Surgery and Radiofrequency for Treatment of Renal Tumors
Treatment of Renal Tumors With Radiofrequency: Efficacy Evaluation in Comparison With Conservative Surgery (Multicentric Randomized Trial)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): lack of patients
Summary
Brief summary (as posted)
Surgical treatment of multiple or recurrent renal tumors may be complicated by renal function impairment. Mini-invasive thermotherapy as radiofrequency (RF), induces necrosis of tumoral tissue while sparing normal renal parenchyma. The purpose of the study is to compare, in patients at risk of renal insufficiency, a strategy based on surgical approach and a strategy based on RF approach. 180 patients from 9 centers will be randomized in two groups (surgical vs. RF, delivered either percutaneously or under laparoscopy). The proportion of patients with a local carcinologic efficacy at 5 years and the general and renal tolerance will be analysed and compared between both strategies.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Kidney Neoplasms | Kidney Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| conservative surgery | Procedure | — | UNRESOLVED |
| Radiofrequency | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Carcinologic efficacy at the site of treatment,
- timeFrame
- at 5 years
Secondary outcomes (3)
- measure
- Overall carcinologic efficacy
- timeFrame
- at 5 years
- measure
- Carcinologic efficacy and lack of adverse consequences on renal function
- timeFrame
- at 5 years
- measure
- Local technical success
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Solid kidney tumor: diameter \<= 40mm, maximum volume 32cc * Intra-parenchymatous localization * At least one of the following criteria: * Patient of more than 70 years old * Hereditary kidney cancer (von Hippel-Lindau Disease disease, hereditary tubulopapillary carcinoma...) * Single kidney, with tumor difficult to reach to a conservative surgery (central-hilar or intra-parenchymatous tumour...) * Context of local recurrence after partial kidney surgery * Patient with impaired renal function (renal clearance \< 30 ml/min) * Written informed consent Exclusion Criteria: * Conservative surgery feasible in good technical and carcinological conditions * Contra-indication to either treatment * Kidney cancer metastases
References
Publications (0)
Data not yet available