Clinical trial · Interventional
Administration of Ketamine to Prevent the Post-operative Pain
Effect of Ketamine, at the Induction and Its Maintenance to Prevent the Post-operative Pain: Clinical Trial in Cancerology
NCT00210210CI-TRIAL-00095470KETAMINEcompletedPhase 3Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The surgery of breast cancer is responsible for post-operative pain, needing in about 30% some morphine consumption; like that, the association of ketamine with general anaesthesia may decrease morphine's use and so its adverse effects. The purpose is to evaluate the analgesic effect of a receptor NMDA's antagonist ( ketamine)
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Postoperative Pain | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ketamine | Drug | — | UNRESOLVED |
| Saline solution | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Ketamine Arm
- description
- Anesthetic induction: Ketamine at 0.15 mg/kg is added to the "Reference protocol". Anesthetic maintenance: Ketamine at 2 mg/kg/min is added to the "Reference protocol".
- interventionNames
- Drug: Ketamine
- type
- SHAM_COMPARATOR
- label
- Reference Arm
- description
- Induction and anesthetic maintenance without ketamine (reference arm / saline solution)
- interventionNames
- Drug: Saline solution
Primary outcomes (1)
- measure
- Morphine Consumption (First 48 Post-operative Hours)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion criteria: * Patients 18 years older * ASA class 1 or 2 * with surgery of breast cancer (mastectomy or tumorectomy) Exclusion criteria: .Kétamine hypersensitivity * Major psychiatric disorders * Major cardio-vascular disorders * Major neurologic disorders * Major ocular disorders * Morphine in pre-operative period
References
Publications (0)
Data not yet available
No reference posted for this study.