Clinical trial · Interventional
Neurosurgical Use of Interstitial Laser Therapy (ILT)
NCT00207350CI-TRIAL-00026130ILTcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The researchers' specific aims are to test the following hypotheses: Hypothesis 1: A tumor can be completely ablated by ILT with MRI-guidance. Hypothesis 2: The MRI-based 3D temperature map of tissue during ILT is predictive of destruction. Hypothesis 3: The 3D "thermal dose" map that is based on the tissue's temperature over time is more predictive of tissue destruction than the temperature map.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Interstitial Laser Therapy | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Brain tumor
- description
- Neurosurgical use of Interstitial Laser therapy
- interventionNames
- Device: Interstitial Laser Therapy
Primary outcomes (1)
- measure
- Ablation of lesion
- timeFrame
- During procedure
Secondary outcomes (1)
- measure
- Patients undergoing ILT will be assessed pre- and post-operatively based on a neurological exam by a physician and patient self-assessment using the Glioma Outcomes Questionnaire
- timeFrame
- 3 Months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Male or female * Age 18+ * Surgically difficult to access tumors including intracerebral metastases Exclusion Criteria: * Patients unwilling or unable to give written consent * Patients at risk for cardiac ischemia * Patients who cannot physically fit in the MRI scanner in the MRI OR * Patients with contraindications to MRI imaging such as pacemakers, non-compatible aneurysm clips, shrapnel, and other internal ferromagnetic objects * Patients with coagulopathies, severe medical problems, cardiac arrhythmias or abnormal BUN
References
Publications (7)
- BACKGROUNDSchulze PC, Vitzthum HE, Goldammer A, Schneider JP, Schober R. Laser-induced thermotherapy of neoplastic lesions in the brain--underlying tissue alterations, MRI-monitoring and clinical applicability. Acta Neurochir (Wien). 2004 Aug;146(8):803-12. doi: 10.1007/s00701-004-0293-5. Epub 2004 Jun 7. PMID 15254802
- BACKGROUNDPeller M, Muacevic A, Reinl H, Sroka R, Abdel-Rahman S, Issels R, Reiser MF. [MRI-assisted thermometry for regional hyperthermia and interstitial laser thermotherapy]. Radiologe. 2004 Apr;44(4):310-9. doi: 10.1007/s00117-004-1032-x. German. PMID 15057421
- BACKGROUNDMcNichols RJ, Gowda A, Kangasniemi M, Bankson JA, Price RE, Hazle JD. MR thermometry-based feedback control of laser interstitial thermal therapy at 980 nm. Lasers Surg Med. 2004;34(1):48-55. doi: 10.1002/lsm.10243. PMID 14755424
- BACKGROUNDLeonardi MA, Lumenta CB. Stereotactic guided laser-induced interstitial thermotherapy (SLITT) in gliomas with intraoperative morphologic monitoring in an open MR: clinical expierence. Minim Invasive Neurosurg. 2002 Dec;45(4):201-7. doi: 10.1055/s-2002-36203. PMID 12494354
- BACKGROUNDKuroda K, Kettenbach J, Nabavi A, Silverman SG, Morrison PR, Jolesz FA. Clinical trials of MR thermography for laser ablation of brain tumors. Journal of the Japanese Society for Magnetic Resonance in Medicine (JMRM) 2002; 21;7,8:298-306.
- BACKGROUNDStraube T, Kahn T. Thermal therapies in interventional MR imaging. Laser. Neuroimaging Clin N Am. 2001 Nov;11(4):749-57. PMID 11995429
- BACKGROUNDMuacevic A, Peller M, Sroka R, Kalusche B, Pongratz T, Kreth FW, Steiger HJ, Reiser M, Reulen HJ. [Brain protective interstitial laser thermotherapy. Therapy of brain tumors without secondary damage]. MMW Fortschr Med. 2001 May 28;143 Suppl 2:87-8. German. PMID 11434269