Clinical trial · Interventional
Study of Unilateral Neck Irradiation in Patients With SCC of the Head and Neck
A Randomized Prospective Evaluation of Unilateral/Ipsilateral Neck Irradiation in Selected Patients With Squamous Cell Carcinoma of the Head and Neck Who Are Managed by Radiation Therapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to assess the feasibility of avoiding opposite side neck radiation therapy in patients with clearly one side squamous cell cancer of the head and neck. We aim to assess the reduction in treatment volume (amount of radiation therapy required), and the resultant xerostomia and mucositis, with the delivery of unilateral neck radiation therapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Squamous Cell Carcinoma of the Head and Neck | Head and Neck Squamous Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| definitive external beam radiation in the ipsilateral neck | Radiation | — | UNRESOLVED |
| Radiation therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- unilateral radiation therapy
- description
- definitive external beam radiation in the ipsilateral neck.
- interventionNames
- Radiation: Radiation therapy
- Radiation: definitive external beam radiation in the ipsilateral neck
Primary outcomes (1)
- measure
- FACT (head and neck);Xerostomia related Quality of Life Questionnaire
- timeFrame
- September 2010
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Squamous cell carcinoma of the oral cavity or oropharynx, with the primary lesion \>1 cm from the midline. * Patient has no clinical or radiologic evidence of contralateral neck node metastases. * No evidence of distant metastasis. * No previous history of radiation therapy or chemotherapy * performance status 0-2 * Age \>= 18 * Signed informed consent * Patients must be accessible for treatment and follow-up Exclusion Criteria: * HIV positive patients * Pregnancy or any patients not practicing contraception * Active tobacco or alcohol addiction (as assessed by medical caregiver) * Serious comorbid disease which prevents delivery of full treatment including psychiatric disorders, cardiopulmonary disease, etc. * Concomitant use of any trial anticancer therapeutic within 30 days of entry * Uncontrolled hypertension * Known hypersensitivity to mammalian cell-derived products
References
Publications (0)
Data not yet available