Clinical trial · Interventional
Hypertonic Saline 75% vs Mannitol 20%
Comparison of Equiosmolar Doses of Mannitol 20% Versus Hypertonic Saline 7.5% Infusion in the Reduction of Brain Bulk During Elective Craniotomies for Supratentorial Brain Tumor Resection
NCT00199511CI-TRIAL-00035628completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate the effect of Hypertonic Saline 7.5% vs Mannitol 20% on brain bulk (using a 4 point scale), intracranial pressure (subdural catheter)and the changes on serum and urinary Na, K and Osmolarity during elective craniotomy for brain tumor resection.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasm | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
| Neoplasm, Supratentorial | Supratentorial Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Tumor, Brain | Brain Neoplasm | ALIAS | 0.90 |
| Tumor, Supratentorial | Supratentorial Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Administration of Hypertonic Solution 7.5% vs Mannitol 20% | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Surgeon's assessment of brain bulk.
- measure
- ICP reduction
Secondary outcomes (2)
- measure
- Changes in intracranial pressure
- measure
- Changes in serum and urine levels of sodium, potassium and osmolarity.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * ASA physical status I - 3. * Age \>18 years. * Scheduled for elective craniotomies for supratentorial brain tumour resection. * Written informed consent. Exclusion Criteria: * Within the past six months, a history of unstable angina pectoris and/or having a myocardial infarction. * Electrocardiogram abnormalities indicating severe ischemia. * Congestive heart failure. * Glasgow coma sore \< 9 * Refusal to participate or refusal to agree to randomization. * Known renal failure * Known poorly controlled diabetes.
References
Publications (0)
Data not yet available
No reference posted for this study.