Clinical trial · Interventional
Three Field Radical Esophagectomy Versus Two Field Esophagectomy - a Prospective Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Surgery is the standard treatment for esophageal (food pipe) cancer. Esophageal cancer is known to spread to the lymph nodes (glands) adjacent to the esophagus. The extent of lymph nodes that need to be removed along with removal of the esophagus is a controversial topic. The basic surgery will remain the same i.e., the foodpipe in the chest will be removed and a new substitute will be created from the stomach and joined to the foodpipe in the neck. This will involve incisions in the chest, abdomen and neck. We intend to compare two types of lymphadenectomy (removal of lymph nodes) - the two field lymphadenectomy, whereby the lymph nodes in the abdomen and the lower half of the chest will be removed and three field lymphadenectomy, wherein lymph nodes in the abdomen, the whole chest and the lower neck will be removed. Both these procedures are practised widely worldwide and there is no definite scientific evidence showing the superiority of either of them. We are conducting this study to see whether one of these procedures is superior to the other. Seven hundred patients are expected to participate in this study.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer of Esophagus | Malignant Esophageal Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Two field vs Three field lymphadenectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Overall survival
Secondary outcomes (2)
- measure
- Disease-free survival
- measure
- Quality of Life
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with biopsy or cytology proven (squamous or adenocarcinoma) esophageal cancer * Patients with staging investigations showing operability * Surgical plan of total transthoracic esophagectomy Exclusion Criteria: * Patients with low performance status (ECOG score\>1) * Past history of malignancy * Staging investigations indicating advanced disease * Patients medically unfit for surgical resection * Patients with pulmonary reserve inadequate to undergo thoracotomy and extensive mediastinal lymphadenectomy * Patients considered for salvage surgery after definitive (radical)chemoradiotherapy * Patients with supracarinal lymph node enlargement on CT scan and/or EUS * Patients intraoperatively detected to have grossly enlarged supracarinal lymph nodes * Patients with Siewert's type III CO junction growths * Patients above the age of 70 years * Patients unreliable for follow up
References
Publications (0)
Data not yet available