Clinical trial · Interventional
Weekly Topotecan in Patients Treated for Metastatic Colorectal Cancer
Phase II Study of Weekly Topotecan in Patients Treated for Metastatic Colorectal Cancer
NCT00193167CI-TRIAL-00004768completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This non-randomized phase II study is designed to assess the response rate and toxicity of weekly topotecan as second-line treatment in patients with relapsed or refractory metastatic colorectal cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Topotecan | Drug | Topotecan | ALIAS |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- overall response rate
Secondary outcomes (3)
- measure
- median survival
- measure
- one year survival
- measure
- toxicity
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: To be included in this study, you must meet the following criteria: * Metastatic colorectal cancer * One previous chemotherapy for metastatic disease * Measurable or evaluable disease * Able to perform activities of daily living with assistance * Adequate bone marrow, liver, and kidney function * All patients must give written informed consent prior to study entry. Exclusion Criteria: You cannot participate in this study if any of the following apply to you: * Brain or meningeal involvement * Serious active infection or underlying medical conditions * Other active neoplasms are ineligible * Pregnant or lactating Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
References
Publications (0)
Data not yet available
No reference posted for this study.