Clinical trial · Interventional
A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects
A Phase II Study of Image-Guided Radiation Therapy for Pediatric CNS Tumors and Quantification of Radiation-Related CNS Effects
NCT00187226CI-TRIAL-00066773completedPhase 2Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of the study was to determine if treating a limited volume of normal tissue surrounding the tumor or tumor bed using conformal radiation therapy would achieve similar rates of disease control compared to standard radiation therapy. The study was also conducted to examine the effect of irradiation on neurological, endocrine and cognitive function.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumors | Brain Neoplasm | ALIAS | 0.90 |
| Central Nervous System Tumors | Central Nervous System Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Radiation Therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Stratum 1
- description
- Ependymoma, craniopharyngioma, low-grade glioma
- interventionNames
- Procedure: Radiation Therapy
- type
- OTHER
- label
- Stratum 2
- description
- High-grade glioma
- interventionNames
- Procedure: Radiation Therapy
Primary outcomes (1)
- measure
- Local Tumor Control
- timeFrame
- 12 months after the enrollment of the last therapeutic patient
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 8 Months
- Maximum age
- 25 Years
Show eligibility criteria text
Inclusion Criteria: * Age at time of irradiation is greater than or equal to 8 months and less than or equal to 25 years * Histologically diagnosed craniopharyngioma, ependymoma, low-grade astrocytoma or high-grade glioma and radiographically diagnosed selected patients with craniopharyngioma and low-grade glioma. * Adequate performance status, participant has an ECOG (Performance Status Score) of 0-2(0=Normal Activity; 1=Symptoms but Ambulatory; 2=Bedridden \<50% of time) * Histologic type that requires only focal irradiation. * No prior fractionated external beam irradiation * Informed consent signed by patient, parent, or guardian.
References
Publications (1)
- DERIVEDNetson KL, Conklin HM, Wu S, Xiong X, Merchant TE. Longitudinal investigation of adaptive functioning following conformal irradiation for pediatric craniopharyngioma and low-grade glioma. Int J Radiat Oncol Biol Phys. 2013 Apr 1;85(5):1301-6. doi: 10.1016/j.ijrobp.2012.10.031. Epub 2012 Dec 11. PMID 23245284