Clinical trial · Observational
Rasburicase Treatment for Chemotherapy or Malignancy-Induced Hyperuricemia in Asthma/Allergy Patients
A Study of Rasburicase Treatment for Chemotherapy of Malignancy-Induced Hyperuricemia in Patients With a History of Asthma Allergies
NCT00186940CI-TRIAL-00027159completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a multi-center trial for rasburicase in children at high risk of tumor lysis syndrome who have a history of asthma/atopy. The main purpose of this study is to establish the safety of this drug in patients with a history of asthma or severe allergies.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Rasburicase | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- 1
- interventionNames
- Drug: Rasburicase
Primary outcomes (1)
- measure
- Incidence of grade 3 or 4 allergic reactions
- timeFrame
- Within 30 days of last treatment administration
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * A diagnosis of hematologic malignancy. * Existing hyperuricemia or high risk of developing hyperuricemia of malignancy. * The treating clinician plans to treat the patient with rasburicase. A patient is only eligible for RASALL if the clinician has already decided to use rasburicase. Rasburicase should not be given in order to make a patient eligible for this non-therapeutic observational study. * No prior exposure to rasburicase or other urate oxidase. * A history of asthma or significant allergy. Exclusion Criteria * Wheezing or an active hypersensitivity reaction at entry. * Hypersensitivity to Aspergillus proteins.
References
Publications (0)
Data not yet available
No reference posted for this study.