Clinical trial · Interventional
Switching From Morphine to Methadone. A Clinical, Pharmacological and Pharmacogenetic Study
NCT00184496CI-TRIAL-00013911completedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cancer patients on morphine for chronic pain, with side effects or unsatisfactory pain relief, will be rotated to Methadone. We will try to find out what is the best methode to rotate, and the equivalent dosage.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Methadone | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- methadon
- description
- Morphine methadone stop and go switch
- interventionNames
- Drug: Methadone
- type
- ACTIVE_COMPARATOR
- label
- Methadone
- description
- Methadon morphine overlap switch
- interventionNames
- Drug: Methadone
Primary outcomes (1)
- measure
- The overall aim of the present study is to validate the switching procedure from morphine to methadone for patients with advanced cancer and a short life expectancy. More specifically, we will:
- timeFrame
- 2 weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * • Malignant disease. * On morphine and in need of opioid rotation. (A patient in need of opioid rotation is defined as having insufficient pain control with or without unacceptable side effects from opioids). * Able to complete the planned assessment schedules. * Above 18 years of age. * If out-patient, the patient lives with someone who can observe him/her. * Given informed consent according to the ethical guidelines. Exclusion Criteria: * Not able to read or write in Norwegian * The patient has participated in a clinical study 4 weeks prior to inclusion
References
Publications (1)
- RESULTMoksnes K, Dale O, Rosland JH, Paulsen O, Klepstad P, Kaasa S. How to switch from morphine or oxycodone to methadone in cancer patients? a randomised clinical phase II trial. Eur J Cancer. 2011 Nov;47(16):2463-70. doi: 10.1016/j.ejca.2011.06.047. Epub 2011 Jul 19. PMID 21775131