Clinical trial · Interventional
High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood
Treatment Protocol for High-Risk PNET Brain Tumors in Children With Surgery, Sequential Chemotherapy, Conventional and High-Dose With Peripheral Blood Stem Cell Transplantation and Radiation Therapy
NCT00180791CI-TRIAL-00000874unknownPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate the efficacy of the combination of surgery, conventional chemotherapy, sequential high-dose chemotherapy with peripheral blood stem cell transplantation and reduced dose radiation therapy in high-risk PNET brain tumors.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumors | Brain Neoplasm | ALIAS | 0.90 |
| Medulloblastoma | Medulloblastoma | CURATED_BROADER | 0.80 |
| Neuroectodermal Tumors, Primitive | Primitive Neuroectodermal Tumor | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Etoposide, carboplatin, melphalan, cisplatin, thiotepa | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Response of medulloblastoma metastases to the chemotherapy regimen in children less than 5 years of age
- measure
- Progression-free survival of children less than 10 years of age with brain PNET
Secondary outcomes (3)
- measure
- Progression-free survival of children less than 5 years of age with metastatic medulloblastoma
- measure
- Toxicity
- measure
- Long term sequelae
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 10 Years
Show eligibility criteria text
Inclusion Criteria: * Medulloblastoma in patients less than 5 years of age * Brain PNET in patients less than 10 years of age * Histologically documented diagnosis * Body weight of \> 8 kg Exclusion Criteria: * Parents' refusal
References
Publications (0)
Data not yet available
No reference posted for this study.