Tandem Peripheral Blood Stem Cell (PBSC) Rescue for High Risk Solid Tumors

Inclusion Criteria:

* Malignant Diseases:

  * Ewing's sarcoma/PNET:

    * CR1 - Metastatic disease at diagnosis, tumor volume \> 100 ml, pelvic bone primary
    * CR2 - Locally recurrent disease
  * Soft tissue sarcoma

    * CR1 - Metastatic disease at diagnosis or locally advanced disease where local control is suboptimal (i.e., inability to provide radiation therapy due to extent of disease).
    * CR2 - Locally recurrent disease (VGPR2 acceptable)
  * Hepatoblastoma:

    * VGPR1 - Patients with metastatic disease at diagnosis who have a persistently elevated alpha FP, or unresectable primary as a way of converting to resectable.
    * CR2/VGPR2
  * Hodgkin's Disease:

    * VGPR1 - Progression on primary therapy/Refractory disease
    * CR2/VGPR2
  * Germ Cell Tumor:

    * CR2/VGPR2 - recurrent disease
  * Wilms Tumor:

    * CR2/VGPR2 - recurrent disease
* IRB approved signed written informed consent by patient and/or their legally authorized guardian.
* Patients 21 years of age or younger at initial diagnosis, with older patients considered individually for primary pediatric disease diagnosis.
* Adequate central venous access (double lumen CVL or 2 single lumen PCVC).
* Adequate PBSC harvests with a minimum of 2.0 x 108 MNC/kg available for each PBSC rescue.
* Organ Function:

  * Platelets \> 50,000/ml
  * SGOT \< 10 x upper limits of normal
  * Creatinine \< 1.5 x normal baseline
  * Normal cardiac function in accordance with institutional policies
  * Normal pulmonary function in accordance with institutional policies.
* Physiologic status:

  * No active infections
  * Adequate performance status as measured by Karnofsky (\> 70%) or Lansky scale (\> 60%) as appropriate for age.
* Bone Marrow Status

  * No evidence of morphologic involvement with tumor at the time of transplant

Off Study Criteria:

* Severe toxicity. Contact the Study Coordinator immediately and complete Adverse Reaction Form.
* Disease progression or relapse prior to PBSC #1 or between PBSC rescue # 1 and #2.
* Inability to collect adequate numbers of PBSC for successful transplantation.
* Patient or parent/guardian refusal to remain on study.