Clinical trial · Observational
Breast MRI Screening in Women Treated With Mediastinal Irradiation for Hodgkin's Disease
NCT00165412CI-TRIAL-00038419completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine if the use of breast MRI in detecting breast malignancies in survivors of Hodgkin's disease is more successful than the traditional mammogram.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Hodgkin's Disease | Hodgkin Lymphoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| breast MRI | Procedure | — | UNRESOLVED |
| Mammogram | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- To compare the sensitivity, specificity, positive and negative predictive value of mammography and breast MRI for breast cancer detection in women treated for Hodgkin's disease.
- timeFrame
- 5 years
Secondary outcomes (3)
- measure
- To describe the MRI appearance and enhancing characteristics of breast cancer after Hodgkin's disease
- timeFrame
- 5 years
- measure
- to correlate the breast MRI findings and pathological findings
- timeFrame
- 5 years
- measure
- to determine the incidence of interval breast cancer in the screened population.
- timeFrame
- 5 years
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Female patients treated with radiation therapy to the chest area for Hodgkin's disease * Age between 12 and 35 at initial treatment * Eight years or longer after initial treatment * Pre-approval from the participant's insurance company for the breast imaging studies Exclusion Criteria: * Pregnant or lactating women * Post Bilateral mastectomy * Currently undergoing breast cancer therapy * Known metastatic cancer * Patients with contraindications for undergoing an MRI: cardiac pacemaker, known metallic objects in body e.g. metallic clips, bullets, shrapnel or buckshots.
References
Publications (1)
- DERIVEDNg AK, Garber JE, Diller LR, Birdwell RL, Feng Y, Neuberg DS, Silver B, Fisher DC, Marcus KJ, Mauch PM. Prospective study of the efficacy of breast magnetic resonance imaging and mammographic screening in survivors of Hodgkin lymphoma. J Clin Oncol. 2013 Jun 20;31(18):2282-8. doi: 10.1200/JCO.2012.46.5732. Epub 2013 Apr 22. PMID 23610104