Open Label Trial for Post-Menopausal Women With Newly Diagnosed Operable Breast Cancer

Inclusion Criteria:

* Pathologically confirmed invasive ductal carcinoma or invasive lobular carcinoma of the breast, T2-T4 / T4a-c / N0-2 / M0, with positive estrogen and/or progesterone receptors. Patients with inflammatory breast cancer will not be included (Stage IIIb). Patients previously treated patients with no measurable disease or patients with metastatic disease will be excluded.
* Written informed consent prior to study specific screening procedures, with the understanding that the patient has the right to withdraw from the study at any time, without prejudice (see Appendix B - consent form).
* Females 60 years of age (postmenopausal).
* Be ambulatory (outpatient) and have an ECOG PS \<2 (Appendix F).
* Patients must have measurable disease by mammogram and/or breast ultrasound. The target lesion must not have been previously irradiated.
* No prior chemotherapy.
* Patients must have adequate organ and marrow function as defined as follows: absolute neutrophil count \> 1,500/mm3, hemoglobin \> 8.0 g/dl, platelets \> 75,000/mm3, total bilirubin \< 2 mg/dl, serum creatinine \< 2 mg/dl, Transaminases (AST, ALT) may be up to 2.0 x institutional upper limit of normal. In addition \< 1 gr of protein in 24 hr urine collection and urine protein/creatinine ratio \< 1.0.
* No life threatening parenchymal disease or rapidly progressing disease warranting cytotoxic chemotherapy.
* Hypertension must be controlled (\<150/100 mmHg).
* Ejection Fraction \> 50%.
* No history of thrombosis during the previous year.

Exclusion Criteria:

* Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study other than this sponsor-investigator Bevacizumab cancer study.
* Uncontrolled high blood pressure (150/100 mmHg)
* Unstable angina
* New York Heart Association (NYHA) Grade II or greater congestive heart failure see Appendix G)
* History of myocardial infarction within 6 months
* History of stroke within 6 months
* Clinically significant peripheral vascular disease
* History of a bleeding disorder
* Presence of central nervous system or brain metastases
* Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 0, anticipation of need for major surgical procedure during the course of the study
* Minor surgical procedures, fine needle aspirations or core biopsies within 7 days prior to Day 0
* Pregnant (positive pregnancy test) or lactating
* Urine protein: creatinine ratio 1.0 at screening. Patients demonstrating \> 1 gr of protein in 24 hr urine collection within 4 weeks prior to study entry will not participate in the trial.
* History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to Day 0
* Serious, non-healing wound, ulcer, or bone fracture
* Unwilling or unable to comply with the protocol for the duration of the study.
* Psychiatric illness/social situations that would limit compliance with study requirements.
* History of another malignancy within the last five years except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix.
* Patients with metastatic disease.