Clinical trial · Interventional
Cleansing of Suction Blood in Cardiac Surgery for Reduced Inflammatory Response
Does Cleansing of Suction Blood During Cardiac Surgery With Heart and Lung Machine Reduce the Postoperative Inflammatory Response ?
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): For financial and logistical reasons
Summary
Brief summary (as posted)
Cardiac surgery using heart and lung machine produces an inflammatory reaction in the body. This leads in few percent of cases to heart, lung, and kidney disturbances that potentially causes death. White blood cells in contact with the heart and lung machine and external surfaces release mediators partly responsible for this. Blood collected by the suction and the blood remaining in the heart and lung machine after its use, can be cleaned by a cell saver before reinfusion, and this might reduce the inflammatory response.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Coronary Arteriosclerosis | — | UNRESOLVED | — |
| Systemic Inflammatory Response Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cell saver | Procedure | — | UNRESOLVED |
| No cell saver | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 1
- description
- With cell saver
- interventionNames
- Procedure: Cell saver
- type
- ACTIVE_COMPARATOR
- label
- 2
- description
- Without cell saver
- interventionNames
- Procedure: No cell saver
Primary outcomes (1)
- measure
- Concentrations of IL-1B, IL-6, IL-8, IL-10, IL-12p70, TNFa, TNF-R1, TNF-R2, PCT and LPS in patient blood.
- timeFrame
- 6, 24 and 72 hours after termination of CPB.
Secondary outcomes (3)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Oral and written informed consent. * No limits regarding age or ejection fraction. Exclusion Criteria: * Off-pump coronary artery bypass grafting * Redo CABG * Current infection * Antibiotic treatment * S-creatinin \> 200 micromol/L * Antiinflammatory / immuno-modulating treatment: Steroids, immunosuppressive or -stimulating agents (NSAIDs and ASA allowed) * Liver disease * Immune disease
References
Publications (0)
Data not yet available