Clinical trial · Interventional
Weekly TP-HDFL in the Treatment of Advanced TCC
A Phase II Study of Weekly Paclitaxel, Cisplatin and 24-Hour Infusion of High-Dose 5-Fluorouracil and Leucovorin(Weekly TP-HDFL) in the Treatment of Advanced Transitional Cell Carcinoma(TCC)
NCT00154687CI-TRIAL-00000814completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate the efficacy of Weekly TP-HDFL in advanced transitional cell carcinoma in terms of response rate and overall survival.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Transitional Cell Carcinoma | Transitional Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Paclitaxel, Cisplatin, 5-Fluorouracil | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- A
- interventionNames
- Drug: Paclitaxel, Cisplatin, 5-Fluorouracil
Primary outcomes (1)
- measure
- response rate
- timeFrame
- 2000~2005
Secondary outcomes (1)
- measure
- Overall Survival ,Safety
- timeFrame
- 2000~2005
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Pathology proven TCC Recurrent or metastatic TCC Muscle-invasive TCC 2. Measurable disease 3. Age\>18 4. KPS\>60﹪ 5. Creatinine clearance\>35ml/min, 6. AST/ALT \< or = 3.5times upper limits of normal reference values 7. Bilirubin\< or = 2.0 mg/dl 8. WBC \> or = 4,000/mm3, PLT \> or = 100,000/mm3 9. Written informed consent Exclusion Criteria: 1. Previous systemic chemo is not allowed 2. TG \<70mg/dl 3. CNS metastasis 4. Life expectancy less than 3 months
References
Publications (0)
Data not yet available
No reference posted for this study.