Clinical trial · Interventional
Orthotopic Liver Transplantation Using a Living Donor
Orthotopic Liver Transplantation Using a Living Donor Into An Adult Recipient
NCT00152607CI-TRIAL-00012282terminatedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Poor accrual
Summary
Brief summary (as posted)
The purpose of this study is to: determine the safety of donor right hepatic lobectomy as a procedure to provide a liver graft for living donor liver transplantation. study the regeneration of liver tissue by volumetric testing for both donor and recipient. assess if graft and patient survival with living donor transplantation is comparable to that of cadaveric donor transplantation.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Disease | — | UNRESOLVED | — |
| Liver Neoplasms | Liver Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| donor right hepatic lobectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- The primary outcome for donors in this study will be the determination of whether right hepatic lobectomy is a safe procedure for the donor as measured by survival, the incidence of surgical complications, liver function and regeneration studies.
- timeFrame
- post transplant
- measure
- The primary outcome for recipients will be the assessment of patient and graft survival. Comparison to results of contemporaneous, non-randomized cadaver donor transplants will be made.
- timeFrame
- post transplant
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 55 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age 18-55 2. No current or prior history of heart, lung or other medical problems. 3. No history of liver disease. 4. No history of malignancy, except limited basal cell carcinoma. 5. ABO / HLA compatibility with the recipient. 6. If female and premenopausal, a negative pregnancy test. 7. Related to recipient either by blood or marriage and having a stable, long term, emotional relationship. 8. The donor's body size and volumetric determination of liver mass by abdominal CT scan will indicate whether or not a donor is a suitable candidate for liver donation if the donor meets the other inclusion criteria. Favorable donors for the individual organs will be those with donor graft to recipient body dry weight ratios (GRBWR) of \>0.7% and those with a ratio of graft volume to recipient's expected liver volume (GWRLW) of \>35%. 9. Satisfactory psychosocial evaluation. - Exclusion Criteria: Recipient Exclusion Criteria: 1. Pregnant or nursing females. 2. Patients with significant concomitant infections. 3. Patients who require multiple organ transplants. 4. Significant pulmonary disease. If pulmonary disease is clinically suspected, diagnostic studies will be performed to exclude the presence of pulmonary hypertension (PA systolic pressure \>40 mm Hg) or arterial saturation (Po2\<60 mmHg, breathing room air). 5. Patients at a higher than average perioperative risk secondary to severe decompensated liver disease or previous surgery (i.e., re-transplantation) or infections. \-
References
Publications (0)
Data not yet available
No reference posted for this study.