Clinical trial · Observational
An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Doctors will take some tissue from the tissue removed during surgery in order to study how the blood vessels of the tumor respond to radiation therapy. The tissue obtained will be used to determine how these tumor blood vessels respond to radiation therapy delivered to the tumor, after it has been removed. This radiation is delivered in the research lab. This research is being conducted in order to develop new methods to treat tumors by radiation therapy. No additional surgery will be performed to obtain these samples, and only materials that remain after all diagnostic testing has been completed will be used.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Liposarcoma | Liposarcoma | ONTOLOGY_EXACT | 0.90 |
| Melanoma | Melanoma | ONTOLOGY_EXACT | 0.98 |
| Ovarian Neoplasms | Ovarian Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Small Cell Lung Cancer | Lung Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ionizing radiation (IR) | Radiation | — | UNRESOLVED |
| Ionizing radiation (IR) therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- A
- description
- The experiments in Group A will be conducted in order to determine if human tumor microvascular endothelium displays similar dose parameters as mouse tumor endothelium, and if the microvascular endothelium of tumors of different types behaves in a similar fashion in its response to IR.
- interventionNames
- Radiation: Ionizing radiation (IR) therapy
- label
- B
- description
- The experiments in Group B will be conducted in order to determine if tumor endothelium isolated to near homogeneity demonstrates dose parameters similar to those used in single dose radiotherapy of brain tumors.
- interventionNames
- Radiation: Ionizing radiation (IR)
Primary outcomes (1)
- measure
- apoptotic response
- timeFrame
- 2 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: * Patients who are felt to have adequate tumor volume for these studies, at least a 2 x 2 x 2 cm3 tumor by physical exam, imaging studies or colonoscopy reports * Primary or recurrent tumors are eligible * Patients must be suitable candidates for surgery * Patients who have signed the informed consent Exclusion Criteria: * Patients who are not considered suitable candidates for surgery * Patients who have received prior radiation therapy to the tumor being removed * Patients who have received chemotherapy within 6 months of tumor removal * Patients who are pregnant * Patients may choose to be excluded at any time * Minors are excluded from this study because there are expected to be very few minors with the tumor types which the investigators are evaluating in this study
References
Publications (0)
Data not yet available