BL22 Immunotoxin in Treating Patients With Refractory Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, or Non-Hodgkin's Lymphoma

DISEASE CHARACTERISTICS:

* Diagnosis of B-cell leukemia or lymphoma of 1 of the following types:

  * Chronic lymphocytic leukemia

    * Failed standard chemotherapy
  * Prolymphocytic leukemia

    * Failed standard chemotherapy
  * Indolent non-Hodgkin's lymphoma, including mantle cell lymphoma

    * Stage III or IV disease
    * Failed ≥ 1 prior doxorubicin- or fludarabine-containing standard therapy
* CD22-positive disease, as evidenced by 1 of the following:

  * More than 15% malignant cells react with anti-CD22 by immunohistochemistry
  * More than 30% malignant cells are CD22-positive by fluorescence-activated cell sorting analysis
  * More than 400 CD22 sites per malignant cell (average) by radiolabeled anti-CD22 binding
* Treatment is medically indicated, as evidenced by any of the following:

  * Progressive disease-related symptoms
  * Progressive cytopenias due to marrow involvement
  * Progressive or painful splenomegaly or adenopathy
  * Rapidly increasing lymphocytosis
  * Autoimmune hemolytic anemia or thrombocytopenia
  * Increased frequency of infections
* No neutralizing anti-toxin or anti-mouse immunoglobulin G (IgG) antibodies to BL22 or PE38

  * No serum neutralization of \> 75% of the activity of 1 μg/mL of BL22
* No CNS disease requiring treatment
* No hairy cell leukemia

PATIENT CHARACTERISTICS:

Age

* 18 and over

Performance status

* ECOG 0-2

Life expectancy

* More than 6 months

Hematopoietic

* Absolute neutrophil count \> 1,000/mm\^3\*
* Platelet count \> 40,000/mm\^3 NOTE: \*Patients with leukemia are eligible regardless of absolute neutrophil count; Grade III-IV pancytopenia or growth factor dependence allowed if due to disease

Hepatic

* Bilirubin \< 1.5 times upper limit of normal (ULN)
* ALT and AST \< 2.5 times ULN

Renal

* Creatinine ≤ 1.5 mg/dL

Pulmonary

* FEV1 ≥ 60% of predicted
* DLCO ≥ 55% of predicted

Other

* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* HIV negative

PRIOR CONCURRENT THERAPY:

Biologic therapy

* Prior bone marrow transplantation allowed
* More than 3 weeks since prior biologic therapy, including interferon, denileukin diftitox, or LMB-2 immunotoxin
* More than 3 months since prior monoclonal antibody therapy (e.g., rituximab)

Chemotherapy

* See Disease Characteristics
* More than 3 weeks since prior cytotoxic chemotherapy

Endocrine therapy

* More than 1 week since prior steriods

  * Less than 5 doses for non-treatment reasons (e.g., allergy prophylaxis)
  * No evidence of disease response

Radiotherapy

* More than 3 weeks since prior whole-body electron beam radiotherapy

  * Radiotherapy within the past 3 weeks allowed provided the volume of bone marrow treated is \< 10% AND the patient has measurable disease located outside the radiation port

Surgery

* Not specified

Other

* More than 3 weeks since prior retinoids
* More than 3 weeks since other prior systemic therapy for this malignancy