Clinical trial · Interventional
Sublingual Methadone for the Management of Cancer Breakthrough Pain
Evaluation of a Dose Titration Protocol for Sublingual Methadone Hydrochloride for the Management of Cancer-related Breakthrough Pain
NCT00125294CI-TRIAL-00029651completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A dose titration protocol for sublingual methadone hydrochloride for the management of cancer-related breakthrough pain to find the optimal dose.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Pain | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Methadone | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Determine optimal dose titration
- measure
- Determine assessment protocol
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * \> 18 years of age * Experiences episodes of breakthrough pain which respond to opioid therapy * Controlled baseline pain * Cognitive status sufficient for accurate completion of assessment form * Willing to provide written informed consent * Ability to hold a volume of 1 cc of water under the tongue for 5 minutes Exclusion Criteria: * Currently or has received methadone during the previous week * Recent history of substance abuse * Severe respiratory impairment or other contraindications to opioids * Recently received therapies that had the potential to alter pain intensity or response to analgesics * Symptomatic anemia
References
Publications (0)
Data not yet available
No reference posted for this study.