Clinical trial · Interventional
Study Comparing Olanzapine With Haloperidol for the Relief of Nausea and Vomiting in Patients With Advanced Cancer
A Randomized Double-blind, Parallel Group Study Comparing Olanzapine (Zyprexa) With Haloperidol (Novo-peridol) for the Relief of Nausea and Vomiting in Patients With Advanced Cancer
NCT00124930CI-TRIAL-00006085terminatedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Study suspended due to low enrollment
Summary
Brief summary (as posted)
The purpose of this study is to compare the efficacy and safety of Haldol (haloperidol) and olanzapine in the control of chronic nausea with advanced cancer patients who have failed first line antiemetic therapy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Nausea | — | UNRESOLVED | — |
| Neoplasms | Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Haldol | Drug | — | UNRESOLVED |
| Olanzapine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Severity of nausea on days 3 and 5
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * \>18 years of age * Significant nausea/vomiting * Failed maxeran and domperidone * Underlying treatment of causes has failed * Adequate cognitive function * Communicates well Exclusion Criteria: * Partial/complete bowel obstruction * Currently taking Haldol or olanzapine * Has drug induced extrapyramidal symptoms * Parkinson's disease * Undergoing chemotherapy or radiotherapy (RT) to brain, abdomen, stomach or esophagus
References
Publications (0)
Data not yet available
No reference posted for this study.