Clinical trial · Observational

A Study of Gene Polymorphisms and Normal Tissue Radiation Injury in Patients Treated for Breast, Prostate, Brain, Lung, and Head and Neck Cancers

NCT00122239CI-TRIAL-00021364unknownClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

This study will examine, for the first time, the independent contribution of a patient's own genetic makeup to the development of post-radiation complications, permitting the future development of predictive tests to avoid radiation injury. To do this, the investigators will examine gene markers in a series of breast, prostate, brain and lung cancer survivors who have received conformal radiotherapy between 1996 and 2003 at the Cross Cancer Institute and Tom Baker Cancer Centre.

Conditions

Conditions (6)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Breast Cancer	Malignant Breast Neoplasm	CURATED_EXACT	0.92
Carcinoma, Non-Small-Cell-Lung	Lung Non-Small Cell Carcinoma	ALIAS	0.90
Carcinoma, Squamous Cell	Squamous Cell Carcinoma	ONTOLOGY_EXACT	0.98
Glioma	Glioma	ONTOLOGY_EXACT	0.98
Head and Neck Cancer	Malignant Head and Neck Neoplasm	ALIAS	0.90
Prostate Cancer	Malignant Prostate Neoplasm	CURATED_EXACT	0.92

Interventions

Interventions (0)

Data not yet available

No intervention recorded.

Eligibility

Eligibility (as posted)

Sex: All

Show eligibility criteria text

Inclusion Criteria:

* Breast cancer
* Prostate cancer
* Squamous cell carcinoma (SCC) of the head and neck
* Non-small-cell-lung carcinoma (NSCLC)
* Glioma treated by radiotherapy

Exclusion Criteria:

* Follow-up less than 18 months

References

Publications (0)

Data not yet available

No reference posted for this study.

Registry

Dates and enrollment

Start: Jan 1, 2005
Primary completion: Feb 1, 2017
Completion: Feb 1, 2017
First posted: Jul 22, 2005
Last update posted: Mar 16, 2016
Enrollment: 13 (actual)
Lead sponsor: AHS Cancer Control Alberta OTHER
Collaborators: Cross Cancer Institute
Keywords: radiotherapy, radiation toxicity, single nucleotide polymorphism, breast carcinoma, prostate carcinoma, squamous cell carcinoma of the head and neck, lung carcinoma (non-small cell)

Data updated 22 days agoSource updated Mar 16, 2016source: clinicaltrials

Locations

Locations by country (1)

Country	Sites	Recruiting
Canada	1	0

Trial listing is informational. Eligibility is decided by the study team; contact information is on ClinicalTrials.gov.