Clinical trial · Interventional
EUS-FNA in the Pre-Operative Evaluation of Patients With Lung Cancer
EUS-FNA in the Pre-Operative Evaluation of Patients With Lung Cancer: A Randomized Trial
NCT00119470CI-TRIAL-00001076completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial examines the role of EUS-FNA (Oesophageal Endoscopic Ultrasound with Fine Needle Aspiration) as an endoscopic technique for the mediastinal staging of patients with lung cancer. Patients will be randomized to either conventional surgical technique or EUS-FNA.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional Surgical Technique | Procedure | — | UNRESOLVED |
| EUS-FNA | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Percentage of surgical interventions avoided
Secondary outcomes (1)
- measure
- Accuracy of EUS-FNA for mediastinal staging of lung cancer
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients with histological or cytological proof of non small cell lung cancer (NSCLC) or with a high clinical suspicion for lung cancer (but without pathologically confirmed diagnosis from the bronchoscopy or CT guided transthoracal biopsies) in whom the next step is normally a diagnostic or therapeutic surgical intervention * no distant metastases after routine clinical work up (PET is optional, not mandatory) * provision of a written informed consent * recent CT-scan of the thorax (\<28 days before randomization date) * age 18 years or older * clinically fit for surgery Exclusion Criteria: * proof of small cell lung cancer (SCLC) with CWU (bronchoscopy or CT guided transthoracal punction) * stage IV NSCLC * patients with a solitary pulmonary nodule (thus without enlarged mediastinal lymph nodes on CT and without mediastinal PET hot spots) : these do not require further mediastinal investigation * former therapy (chemotherapy or radiotherapy or surgery) for lung cancer * other concomitant malignancies * reasons for which the patient is unable to swallow the EUS-instrument (e.g. zenker diverticulum, unexplained esophageal stenosis) * uncorrected coagulopathy
References
Publications (1)
- DERIVEDTournoy KG, De Ryck F, Vanwalleghem LR, Vermassen F, Praet M, Aerts JG, Van Maele G, van Meerbeeck JP. Endoscopic ultrasound reduces surgical mediastinal staging in lung cancer: a randomized trial. Am J Respir Crit Care Med. 2008 Mar 1;177(5):531-5. doi: 10.1164/rccm.200708-1241OC. Epub 2007 Oct 25. PMID 17962631